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Master regulator: p53’s pivotal role in steering NK-cell tumor patrol

9 Aug 2024

Abstract excerpt

The p53 protein, encoded by TP53, is a tumor suppressor that plays a critical role in regulating apoptosis, cell cycle regulation, and angiogenesis in tumor cells via controlling various downstream signals. Natural killer (NK) cell-mediated immune surveillance is a vital self-defense mechanism against cancer and other diseases, with NK cell activity regulated by various mechanisms. Among these, p53 plays a...

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PMID: 39185404
DOI: 10.3389/fimmu.2024.1428653

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