Article

The accumulation of lncRNAs in hybrid with DNA in patients with psoriasis reveals a decrease in the levels of RNase HII transcripts in the skin

2021-10-14

Abstract excerpt

Long functional non-coding RNAs (lncRNAs) have been in the limelight in aging research because short telomeres are associated with higher levels of TERRA (Telomeric Repeat containing RNA). The genomic instability caused in Immune-mediated inflammatory diseases (IMID) especially in patients with psoriasis, which lead to short telomeres in psoriasis lesions, is a mechanism leading to cell aging. Research on the frac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 47578652-4776-58bf-bd96-19fed56629c0
DOI: 10.1101/2021.10.12.464167

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The accumulation of lncRNAs in hybrid with DNA in patients with psoriasis reveals a decrease in the levels of RNase HII transcripts in the skinDOI 10.1101/2021.10.12.464167Read

Decrease in RNase HII and Accumulation of lncRNAs/DNA Hybrids: A Causal Implication in Psoriasis?Semantic proximity Read

Decreased A-to-I RNA editing as a source of keratinocytes' dsRNA in psoriasisSemantic proximity Read

Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybridsSemantic proximity Read

Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integritySemantic proximity Read

Characterization of Circular RNA Transcriptomes in Psoriasis and Atopic Dermatitis Reveals Disease-specific Expression ProfilesSemantic proximity Read

Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skinSemantic proximity Read

Post-transcriptional regulation via alternative polyadenylation and piRNA shapes macrophage responses in psoriasis.Semantic proximity Read

High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAomeSemantic proximity Read

TElomeric repeat-containing RNA (TERRA): Physiological functions and relevance in cancerSemantic proximity Read

Low-Dose Ionizing Radiation-Crosslinking Immunoprecipitation (LDIR-CLIP) Identified Irradiation-Sensitive RNAs for RNA-Binding Protein HuR-Mediated DecaySemantic proximity Read

RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationshipsSemantic proximity Read

Altered RNA Editing in Atopic Dermatitis Highlights the Role of Double-Stranded RNA for Immune SurveillanceSemantic proximity Read