Article
BRAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumorigenesis.
Cancer science - 1 Jun 2017
Horniblow Richard D, Bedford Matthew, Hollingworth Robert, Evans Sarah, Sutton Emily, Lal Neeraj, Beggs Andrew, Iqbal Tariq H, Tselepis Chris
Abstract excerpt
A role for iron in carcinogenesis is supported by evidence that iron metabolism proteins are modulated in cancer progression. To date, however, the expression of iron regulatory protein-2 (IRP2), which is known to regulate several iron metabolism proteins, has not been assessed in colorectal cancer. Expression of IRP2 was assessed by quantitative RT-PCR and immunohistochemistry in human colorectal cancer tissue....
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