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Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities

5 Dec 2014

Abstract excerpt

Excess iron is tightly associated with tumorigenesis in multiple human cancer types through a variety of mechanisms including catalyzing the formation of mutagenic hydroxyl radicals, regulating DNA replication, repair and cell cycle progression, affecting signal transduction in cancer cells, and acting as an essential nutrient for proliferating tumor cells. Thus, multiple therapeutic strategies based on iron...

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PMID: 25476483
DOI: 10.1007/s13238-014-0119-z

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