Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture.

Stem cell reports - 10 Sept 2024

Glass Madison R, Waxman Elisa A, Yamashita Satoshi, Lafferty Michael, Beltran Alvaro A, Farah Tala, Patel Niyanta K, Singla Rubal, Matoba Nana, Ahmed Sara, Srivastava Mary, Drake Emma, Davis Liam T, Yeturi Meghana, Sun Kexin, Love Michael I, Hashimoto-Torii Kazue, French Deborah L, Stein Jason L

Abstract excerpt

While guided human cortical organoid (hCO) protocols reproducibly generate cortical cell types at one site, variability in hCO phenotypes across sites using a harmonized protocol has not yet been evaluated. To determine the cross-site reproducibility of hCO differentiation, three independent research groups assayed hCOs in multiple differentiation replicates from one induced pluripotent stem cell (iPSC) line...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Culture Techniques
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cerebral Cortex

Share to Induced Pluripotent Stem Cells

Share to Neurons

Share to Organoids

Share to Phenotype

Share to Reproducibility of Results

Source

Open in PubMed Open full text

Identifiers

PMID: 39178845
DOI: 10.1016/j.stemcr.2024.07.008
PMCID: PMC11411306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architecture.PMID 39178845Read ↗

Cross-site reproducibility of human cortical organoids reveals consistent cell type composition and architectureSemantic proximity Read ↗

Robust Production of Uniform Human Cerebral Organoids from Pluripotent Stem CellsSemantic proximity Read ↗

Optimization and scaling of patient-derived brain organoids uncovers deep phenotypes of diseaseSemantic proximity Read ↗

Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility.Semantic proximity Read ↗

Reconstitution of Human Brain Cell Diversity in Organoids via Four ProtocolsSemantic proximity Read ↗

Single-cell multiomics atlas of organoid development uncovers longitudinal molecular programs of cellular diversification of the human cerebral cortexSemantic proximity Read ↗

Validation of non-destructive morphology-based selection of cerebral cortical organoids by paired morphological and single-cell RNA-seq analysesSemantic proximity Read ↗

Taming human brain organoids one cell at a time.Semantic proximity Read ↗

Single organoid RNA-sequencing reveals high organoid-to-organoid variabilitySemantic proximity Read ↗

Dynamic Characterization of Structural, Molecular, and Electrophysiological Phenotypes of Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids, and Comparison with Fetal and Adult Gene Profiles.Semantic proximity Read ↗

Brain regional identity and cell type specificity landscape of human cortical organoid modelsSemantic proximity Read ↗

Highly reproducible human brain organoids recapitulate cerebral cortex cellular diversity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.