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Article

Healthy lifestyle practice correlates with decreased obesity prevalence in individuals with high polygenic risk: TMM CommCohort study.

Journal of human genetics - 1 Jan 2025

Sutoh Yoichi, Hachiya Tsuyoshi, Otsuka-Yamasaki Yayoi, Komaki Shohei, Minabe Shiori, Ohmomo Hideki, Sasaki Makoto, Shimizu Atsushi

Abstract excerpt

Obesity and overweight, fundamental components of the metabolic syndrome, predispose individuals to lifestyle-related diseases. The extent to which adopting healthy lifestyles can reduce obesity risk, even in those with a high genetic risk, remains uncertain. Our aim was to assess the extent to which lifestyle modifications can improve outcomes in individuals with a high polygenic score (PGS) for obesity. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39174808
DOI: 10.1038/s10038-024-01280-3
PMCID: PMC11700849

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