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Article

RAD18 ‐ and BRCA1 ‐dependent pathways promote cellular tolerance to the nucleoside analog ganciclovir

22 Aug 2024

Abstract excerpt

Abstract Ganciclovir (GCV) is a clinically important drug as it is used to treat viral infections. GCV is incorporated into the DNA during replication, where it interferes with subsequent replication on GCV‐incorporated templates. However, the effects of GCV on the host genome and the mechanisms underlying cellular tolerance to GCV remain unclear. In this study, we explored these mechanisms using a collection of...

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PMID: 39169841
DOI: 10.1111/gtc.13155

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