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Article

DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest.

Journal of virology - 1 Oct 2007

Tan Lindi, Ehrlich Elana, Yu Xiao-Fang

Abstract excerpt

Vpr-mediated induction of G2 cell cycle arrest has been postulated to be important for human immunodeficiency virus type 1 (HIV-1) replication, but the precise role of Vpr in this cell cycle arrest is unclear. In the present study, we have shown that HIV-1 Vpr interacts with damaged DNA binding protein 1 (DDB1) but not its partner DDB2. The interaction of Vpr with DDB1 was inhibited when DCAF1 (VprBP) expression...

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Topics

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Share to Cullin Proteins
Share to G2 Phase
Share to Gene Products, vpr

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proteasome Endopeptidase Complex

Share to Proteasome Inhibitors

Share to RNA, Small Interfering

Share to Ubiquitin-Protein Ligases

Share to vpr Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 17626091
DOI: 10.1128/JVI.01380-07
PMCID: PMC2045451

Genes

DDB1
DCAF1
DDB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest.PMID 17626091Read ↗

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