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Article

Tumor-derived RHOA mutants interact with effectors in the GDP-bound state.

Nature communications - 21 Aug 2024

Lin Yuan, Ramelot Theresa A, Senyuz Simge, Gursoy Attila, Jang Hyunbum, Nussinov Ruth, Keskin Ozlem, Zheng Yi

Abstract excerpt

RHOA mutations are found at diverse residues in various cancer types, implying mutation- and cell-specific mechanisms of tumorigenesis. Here, we focus on the underlying mechanisms of two gain-of-function RHOA mutations, A161P and A161V, identified in adult T-cell leukemia/lymphoma. We find that RHOAA161P and RHOAA161V are both fast-cycling mutants with increased guanine nucleotide dissociation/association rates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39169042
DOI: 10.1038/s41467-024-51445-z
PMCID: PMC11339415

Genes

RHOA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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