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Article

Genomewide association study on monoclonal gammopathy of unknown significance (MGUS).

European journal of haematology - 1 Jul 2017

Thomsen Hauke, Campo Chiara, Weinhold Niels, da Silva Filho Miguel Inacio, Pour Luděk, Gregora Evžen, Vodicka Pavel, Vodickova Ludmila, Hoffmann Per, Nöthen Markus M, Jöckel Karl-Heinz, Langer Christian, Hajek Roman, Goldschmidt Hartmut, Hemminki Kari, Försti Asta

Abstract excerpt

OBJECTIVES: To identify germ line variants contributing to the development of monoclonal gammopathy of undetermined significance (MGUS), an asymptomatic premalignant precursor for multiple myeloma (MM). METHODS: We conducted the first genomewide association study (GWAS) on MGUS on 243 German cases with a replication on 294 Czech cases. Identified loci were further analyzed in 1508 German MM patients. New MM loci...

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PMID: 28375557
DOI: 10.1111/ejh.12892

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