Article

The combination of mitogenic stimulation and cell cycle arrest induces senescence in equine and human cartilage explants

2020-03-06

Abstract excerpt

<h4>Objective</h4> Cellular senescence is a phenotypic state characterized by stable cell-cycle arrest, enhanced lysosomal activity, and the secretion of inflammatory molecules and matrix degrading enzymes. Senescence has been implicated in osteoarthritis (OA) pathophysiology; however, the mechanisms that drive senescence induction in cartilage and other joint tissues are unknown. While numerous physiological sig...

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Literature Corpus work: 0b50090d-2fce-5df0-aec1-8c94c8661a36
DOI: 10.1101/2020.03.05.979872

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