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Article

A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 24 Aug 2004

Eswarakumar Veraragavan P, Horowitz Mark C, Locklin Rachel, Morriss-Kay Gillian M, Lonai Peter

Abstract excerpt

The b and c variants of fibroblast growth factor receptor 2 (FGFR2) differ in sequence, binding specificity, and localization. Fgfr2b, expressed in epithelia, is required for limb outgrowth and branching morphogenesis, whereas the mesenchymal Fgfr2c variant is required by the osteocyte lineage for normal skeletogenesis. Gain-of-function mutations in human FGFR2c are associated with craniosynostosis syndromes. To...

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Source

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Identifiers

PMID: 15316116
DOI: 10.1073/pnas.0405031101
PMCID: PMC515096

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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