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Two novel compounds inhibit Flavivirus infection in vitro and in vivo by targeting lipid metabolism

19 Aug 2024

Abstract excerpt

ABSTRACT Flavivirus infection capitalizes on cellular lipid metabolism to remodel the cellular intima, creating a specialized lipid environment conducive to viral replication, assembly, and release. The Japanese encephalitis virus (JEV), a member of the Flavivirus genus, is responsible for significant morbidity and mortality in both humans and animals. Currently, there are no effective antiviral drugs available...

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PMID: 39158346
DOI: 10.1128/jvi.00635-24

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