Article
A multicenter study on accuracy and reproducibility of nanopore sequencing-based genotyping of bacterial pathogens.
Journal of clinical microbiology - 11 Sept 2024
Dabernig-Heinz Johanna, Lohde Mara, Hölzer Martin, Cabal Adriana, Conzemius Rick, Brandt Christian, Kohl Matthias, Halbedel Sven, Hyden Patrick, Fischer Martin A, Pietzka Ariane, Daza Beatriz, Idelevich Evgeny A, Stöger Anna, Becker Karsten, Fuchs Stephan, Ruppitsch Werner, Steinmetz Ivo, Kohler Christian, Wagner Gabriel E
Abstract excerpt
Nanopore sequencing has shown the potential to democratize genomic pathogen surveillance due to its ease of use and low entry cost. However, recent genotyping studies showed discrepant results compared to gold-standard short-read sequencing. Furthermore, although essential for widespread application, the reproducibility of nanopore-only genotyping remains largely unresolved. In our multicenter performance study...
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