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Detection of Mycobacterium tuberculosis from tongue swabs using sonication and sequence-specific hybridization capture

15 Aug 2024

Abstract excerpt

Tongue swabs hold promise as a non-invasive sample for diagnosing tuberculosis (TB). However, their utility as replacements for sputum has been limited by their varied diagnostic performance in PCR assays compared to sputum. The use of silica-based DNA extraction methods may limit sensitivity due to incomplete lysis of Mycobacterium tuberculosis (MTB) cells and co-extraction of non-target nucleic acid, which may...

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PMID: 39146324
DOI: 10.1371/journal.pone.0308235

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