Article
Comparative evolutionary genetics of spontaneous mutations affecting fitness in rhabditid nematodes.
Proceedings of the National Academy of Sciences of the United States of America - 19 Apr 2005
Baer Charles F, Shaw Frank, Steding Catherine, Baumgartner Margaret, Hawkins Alicia, Houppert Andrew, Mason Nicole, Reed Marissa, Simonelic Kevin, Woodard Wayne, Lynch Michael
Abstract excerpt
Deleterious mutations are of fundamental importance to all aspects of organismal biology. Evolutionary geneticists have expended tremendous effort to estimate the genome-wide rate of mutation and the effects of new mutations on fitness, but the degree to which genomic mutational properties vary within and between taxa is largely unknown, particularly in multicellular organisms. Beginning with two highly inbred...
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