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Article

LEP rs7799039 and LEPR rs1137101 gene variants are not associated with clinical features in patients with metabolic syndrome in the Turkish population.

Laboratory medicine - 6 Jan 2025

Jabbarli Marjan, Senkal Naci, Tuncel Fatima Ceren, Oyaci Yasemin, Guzel Dirim Merve, Kose Murat, Pehlivan Sacide, Medetalibeyoglu Alpay

Abstract excerpt

OBJECTIVES: Genetic predisposition plays a role in the etiology of metabolic syndrome (MetS), an important health problem worldwide. Leptin (LEP), produced by adipose tissue, plays a crucial role in the development of MetS. In this study, we evaluated the effects of LEP and LEP receptor (LEPR) variants on clinical findings and risk of developing MetS in the Turkish population. METHODS: A total of 320 patients...

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Case-Control Studies
Gene Frequency
Leptin
Metabolic Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Receptors, Leptin

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Identifiers

PMID: 39136228
DOI: 10.1093/labmed/lmae061
PMCID: PMC11700887

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