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Article

CYP3A4 Poor and Intermediate Metabolizers Have a Higher Rate of Steroid-Induced Intraocular Pressure Response.

Journal of glaucoma - 1 Feb 2025

Wright Jessica A, Xu Sarah C, Wong Mitchell H, El Melik Razan M, Hodge David, Sit Arthur J

Abstract excerpt

PURPOSE: Evaluate the relationship between CYP3A4 phenotype, the gene encoding the enzyme that metabolizes exogenous steroids, and the rate of steroid-induced intraocular pressure (IOP) response. MATERIALS AND METHODS: Lymphocyte-derived DNA sequencing of CYP3A4 from 10073 patients was completed using the PGRN-Seq assay. Subjects with CYP3A4 intermediate metabolizer or slower phenotypes were identified and...

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Source

Identifiers

PMID: 39133066
DOI: 10.1097/IJG.0000000000002482

Genes

CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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