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Article

RPA3 regulates NSCLC malignant phenotypes through epistatic functional association between GPR87 and p53.

Gene - 5 Dec 2026

Yu Yang, Gao Wenwen, Liu Wenjuan, Ma Hongfu, Wang Haixia

Abstract excerpt

This study aimed to clarify the functional regulatory links among RPA3, GPR87 and p53 in the tumorigenesis and progression of non-small cell lung cancer (NSCLC). Bioinformatic analysis and Western blot assays were performed to evaluate the expression profiles of RPA3 and GPR87 in NSCLC. CCK-8, EdU, wound healing, Transwell and flow cytometry assays were used to explore the effects of RPA3 knockdown on NSCLC...

Read the complete abstract on PubMed

Topics

Humans
Carcinoma, Non-Small-Cell Lung
Tumor Suppressor Protein p53
Lung Neoplasms
Animals
Cell Proliferation
Apoptosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Line, Tumor

Mice

Gene Expression Regulation, Neoplastic

Cell Movement

Receptors, Lysophosphatidic Acid

Epistasis, Genetic

Phenotype

Mice, Nude

A549 Cells

Source

Identifiers

PMID: 42607849
DOI: 10.1016/j.gene.2026.150358

Genes

RPA3
GPR87
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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