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Evaluation of Cyc1 protein stability in Acidithiobacillus ferrooxidans bacterium after E121D mutation by molecular dynamics simulation to improve electron transfer.

Journal of microbiology (Seoul, Korea) - 1 May 2022

Shojapour Mahnaz, Farahmand Somayeh, Fatemi Faezeh, Shasaltaneh Marzieh Dehghan

Abstract excerpt

Cyc1 (Cytochrome c552) is a protein in the electron transport chain of the Acidithiobacillus ferrooxidans (Af) bacteria which obtain their energy from oxidation Fe2+ to Fe3+. The electrons are directed through Cyc2, RCY (rusticyanin), Cyc1 and Cox aa3 proteins to O2. Cyc1 protein consists of two chains, A and B. In the present study, a novel mutation (E121D) in the A chain of Cyc1 protein was selected due to...

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PMID: 35286603
DOI: 10.1007/s12275-022-1645-7

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