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Article

A Phenotypic Approach to the Discovery of Potent G-Quadruplex Targeted Drugs.

Molecules (Basel, Switzerland) - 1 Aug 2024

Neidle Stephen

Abstract excerpt

G-quadruplex (G4) sequences, which can fold into higher-order G4 structures, are abundant in the human genome and are over-represented in the promoter regions of many genes involved in human cancer initiation, progression, and metastasis. They are plausible targets for G4-binding small molecules, which would, in the case of promoter G4s, result in the transcriptional downregulation of these genes. However,...

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Share to Antineoplastic Agents
Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G-Quadruplexes

Share to Gene Expression Regulation, Neoplastic

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Share to Promoter Regions, Genetic

Source

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Identifiers

PMID: 39125057
DOI: 10.3390/molecules29153653
PMCID: PMC11314571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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