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Single nucleotide variants in Pseudomonas aeruginosa populations from sputum correlate with baseline lung function and predict disease progression in individuals with cystic fibrosis

2021-10-05

Abstract excerpt

Complex polymicrobial communities inhabit the lungs of individuals with cystic fibrosis (CF) and contribute to the decline in lung function. However, the severity of lung disease and its progression in CF patients are highly variable and imperfectly predicted by host clinical factors at baseline, CFTR mutations in the host genome, or sputum polymicrobial community variation. The opportunistic pathogen Pseudomonas...

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Literature Corpus work: f66d1d09-8aa9-5ed4-bb98-e93360957a08
DOI: 10.1101/2021.10.04.21264421

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Single nucleotide variants in <i>Pseudomonas aeruginosa</i> populations from sputum correlate with baseline lung function and predict disease progression in individuals with cystic fibrosis

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