Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs

Abstract excerpt

ATP-binding cassette (ABC) transporters are transmembrane proteins expressed commonly in metabolic and excretory organs to control xenobiotic or endobiotic disposition and maintain their homeostasis. Changes in ABC transporter expression may directly affect the pharmacokinetics of relevant drugs involving absorption, distribution, metabolism, and excretion (ADME) processes. Indeed, overexpression of efflux ABC...

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• Drug Transport and Resistance Mechanisms
• MicroRNA in disease regulation
• RNA Interference and Gene Delivery