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Article

Regulation of multidrug resistance by microRNAs in anti-cancer therapy

3 Dec 2016

Abstract excerpt

Multidrug resistance (MDR) remains a major clinical obstacle to successful cancer treatment. Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of drugs transporters, defects of apoptosis and autophagy machinery, alterations of drug metabolism and drug targets, disrupti on of redox homeostasis, the exact mechanisms of MDR in a specific cancer patient and the cross-talk among these...

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PMID: 28119807
DOI: 10.1016/j.apsb.2016.09.002

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