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Article

ATP-binding cassette transmembrane transporters and their epigenetic control in cancer: an overview

26 Jul 2016

Abstract excerpt

INTRODUCTION: Members of the ATP-binding cassette (ABC) transmembrane transporters control the passage of several substrates across cell membranes, including drugs. This means that ABC transporters may exert a significant influence on the kinetics and dynamics of pharmacological agents, being responsible for the occurrence of multidrug-resistant (MDR) phenotype. Pharmacogenetic analyses have shed light on gene...

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PMID: 27459275
DOI: 10.1080/17425255.2016.1215423

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