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Article

Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs.

Hepatology (Baltimore, Md.) - 1 Mar 2012

Borel Florie, Han Ruiqi, Visser Allerdien, Petry Harald, van Deventer Sander J H, Jansen Peter L M, Konstantinova Pavlina

Abstract excerpt

UNLABELLED: Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are drug efflux pumps responsible for the multidrug resistance phenotype causing hepatocellular carcinoma (HCC) treatment failure. Here we studied the expression of 15 ABC transporters relevant for multidrug resistance in 19 paired HCC patient samples (16 untreated, 3 treated by chemotherapeutics). Twelve ABC transporters showed...

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Share to ATP-Binding Cassette Transporters
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Multiple

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Share to Liver Neoplasms

Share to Multidrug Resistance-Associated Protein 2

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Source

Identifiers

PMID: 21932399
DOI: 10.1002/hep.24682

Genes

ABCC1
ABCC10
ABCC5
ABCE1
ABCA1
ABCA2
ABCB1
ABCB6
ABCC11
ABCC12
ABCC2
ABCC3
ABCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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