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Article

Role of microRNAs in the regulation of drug metabolism and disposition

28 Sept 2009

Abstract excerpt

BACKGROUND: The important role of nuclear receptors in transcriptional gene regulation of drug-metabolizing enzymes (DMEs) and drug transporters (DTs) has been well documented. In contrast, there is limited understanding of post-transcriptional gene regulation of DMEs and DTs. MicroRNAs (miRNAs) represent a large group of non-coding RNAs that control the post-transcriptional expression of target genes. Currently,...

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PMID: 19785514
DOI: 10.1517/17425250903307448

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