Article
miRNAs modulate the drug response of tumor cells.
Science in China. Series C, Life sciences - 1 Sept 2009
Wu XueMei, Xiao HuaSheng
Abstract excerpt
Chemotherapy is one of the major treatments of malignant carcinomas. However, its efficiency is affected by both intrinsic and acquired resistance to anticancer drugs. The cellular mechanisms of drug resistance include the overexpression of energy-dependent transporters that eject anticancer drugs from cells such as p-glycoprotein and multidrug resistance related protein (MRP), the mutation of drug targets, the...
Topics
- Drug Resistance, Neoplasm
- Gene Expression
- Humans
- MicroRNAs
- Mutation
- Neoplasms
- RNA, Neoplasm