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[The association of single-nucleotide polymorphism rs6265 of the brain-derived neurotrophic factor gene with clinical features in Parkinson's disease].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2024

Nikitina M A, Bragina E Yu, Nazarenko M S, Alifirova V M

Abstract excerpt

OBJECTIVE: To evaluate the frequency and severity of various clinical symptoms of Parkinson's disease (PD) depending on the BDNF rs6265 polymorphism. MATERIAL AND METHODS: The study included 533 patients with PD. The stage of PD was assessed using the Hoehn and Yahr scale (1967), motor symptoms were evaluated with MDS-UPDRS. Assessment of non-motor symptoms (NMS) in PD was conducted using the Beck Depression...

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PMID: 39113447
DOI: 10.17116/jnevro202412407182

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