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Article

Neonatal Fc receptor is a functional receptor for classical human astrovirus

12 Sept 2024

Abstract excerpt

Human astrovirus (HAstV) is a global cause of gastroenteritis in infants, the elderly, and the immunocompromised. However, the molecular mechanisms that control its susceptibility are not fully understood, as the functional receptor used by the virus has yet to be identified. Here, a genome-wide CRISPR-Cas9 library screen in Caco2 cells revealed that the neonatal Fc receptor (FcRn) can function as a receptor for...

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PMID: 39266307
DOI: 10.1111/gtc.13160

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