Enduring autism-like phenotypes and deregulated hypothalamic prosocial peptides after early-life exposure to indoor flame retardants in male C57BL/6 mice.

doi:10.1111/jne.70237

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Article

Enduring autism-like phenotypes and deregulated hypothalamic prosocial peptides after early-life exposure to indoor flame retardants in male C57BL/6 mice.

Journal of neuroendocrinology - 1 Aug 2026

Kozlova Elena V, Gonzalez Gwendolyn M, Denys Maximillian E, Bishay Anthony E, Gutierrez Roberto, Reid Jack, Krum Julia M, Lampel Gregory, Luvsanravdan Naran, Rabbani Kayhon M, Tu Jordan, Campoy Luis, Anchondo Laura M, Luna Crystal N, Olomi Duraan S, Monarrez Eduardo, Carrillo Valeria, Tran Jasmin D, Platt Damon, Korde Yash, Chinthirla Bhuvaneswari D, Blaibel Maher, Kim Simon, Chompre Gladys, Phillips Allison L, Stapleton Heather M, Henkelmann Bernhard, Schramm Karl-Werner, Curras-Collazo Margarita C

Abstract excerpt

Polybrominated diphenyl ethers (PBDEs) are neuroendocrine-disrupting chemicals that produce adverse neurodevelopmental effects. PBDEs have been implicated as risk factors for autism spectrum disorder (ASD), which is characterized by abnormal psychosocial functioning and is commonly comorbid with cognitive deficits and sensory abnormalities. Here, we used a mouse model with translationally relevant exposure to...

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PMID: 42552960
DOI: 10.1111/jne.70237
PMCID: PMC13439164

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