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Prenatal Environmental Determinants of Aromatase Brain-Promoter Methylation in Cord Blood: Chemical, Airborne, Pharmacological, and Nutritional Factors

2025-07-27

Abstract excerpt

Aromatase, an enzyme encoded by the gene CYP19A1 , plays central roles in neurodevelopment. In the brain, its function is to convert androgens into neuroestrogens, ensuring balanced hormonal signalling. Both animal experiments and human studies have shown that, in males, disruption of aromatase, either genetically or epigenetically, can increase symptoms of autism. Prenatal exposure to bisphenol A (BPA), a common...

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Literature Corpus work
422150f3-f0fc-5a3f-91f2-cd5d821d6d05
DOI
10.1101/2025.07.24.666701
Open publication

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Prenatal Environmental Determinants of Aromatase Brain-Promoter Methylation in Cord Blood: Chemical, Airborne, Pharmacological, and Nutritional FactorsDOI 10.1101/2025.07.24.666701
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