Article
Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71.
Archives of toxicology - 1 Jan 2022
Kozlova Elena V, Valdez Matthew C, Denys Maximillian E, Bishay Anthony E, Krum Julia M, Rabbani Kayhon M, Carrillo Valeria, Gonzalez Gwendolyn M, Lampel Gregory, Tran Jasmin D, Vazquez Brigitte M, Anchondo Laura M, Uddin Syed A, Huffman Nicole M, Monarrez Eduardo, Olomi Duraan S, Chinthirla Bhuvaneswari D, Hartman Richard E, Kodavanti Prasada Rao S, Chompre Gladys, Phillips Allison L, Stapleton Heather M, Henkelmann Bernhard, Schramm Karl-Werner, Curras-Collazo Margarita C
Abstract excerpt
Polybrominated diphenyl ethers (PBDEs) are ubiquitous persistent organic pollutants (POPs) that are known neuroendocrine disrupting chemicals with adverse neurodevelopmental effects. PBDEs may act as risk factors for autism spectrum disorders (ASD), characterized by abnormal psychosocial functioning, although direct evidence is currently lacking. Using a translational exposure model, we tested the hypothesis that...
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