Article
Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis.
EBioMedicine - 1 Jul 2020
Zhao Fei, Zhang Dake, Zhou Qingyi, Zhao Fuxin, He Mingguang, Yang Zhenglin, Su Yongchao, Zhai Ying, Yan Jiaofeng, Zhang Guoyun, Xue Anquan, Tang Jing, Han Xiaotong, Shi Yi, Zhu Yun, Liu Tianzi, Zhuang Wenjuan, Huang Lulin, Hong Yaqiang, Wu Deng, Li Yingxiang, Lu Qinkang, Chen Wei, Jiao Shiming, Wang Qiongsi, Srinivasalu Nethrajeith, Wen Yingying, Zeng Changqing, Qu Jia, Zhou Xiangtian
Abstract excerpt
BACKGROUND: Myopia is a good model for understanding the interaction between genetics and environmental stimuli. Here we dissect the biological processes affecting myopia progression. METHODS: Human Genetic Analyses: (1) gene set analysis (GSA) of new genome wide association study (GWAS) data for 593 individuals with high myopia (refraction ≤ -6 diopters [D]); (2) over-representation analysis (ORA) of 196 genes...
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