Article
Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia.
Nature genetics - 1 Apr 2020
Hysi Pirro G, Choquet Hélène, Khawaja Anthony P, Wojciechowski Robert, Tedja Milly S, Yin Jie, Simcoe Mark J, Patasova Karina, Mahroo Omar A, Thai Khanh K, Cumberland Phillippa M, Melles Ronald B, Verhoeven Virginie J M, Vitart Veronique, Segre Ayellet, Stone Richard A, Wareham Nick, Hewitt Alex W, Mackey David A, Klaver Caroline C W, MacGregor Stuart, Khaw Peng T, Foster Paul J, Guggenheim Jeremy A, Rahi Jugnoo S, Jorgenson Eric, Hammond Christopher J
Abstract excerpt
Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the molecular mechanisms that underlie abnormal eye development and impaired vision. We conducted a meta-analysis of genome-wide association studies (GWAS) that involved 542,934 European participants and identified 336 novel genetic loci associated with refractive...
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