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Article

Genomic complexity is associated with epigenetic regulator mutations and poor prognosis in diffuse large B-cell lymphoma.

Oncoimmunology - 1 Jan 2021

You Hua, Xu-Monette Zijun Y, Wei Li, Nunns Harry, Nagy Máté L, Bhagat Govind, Fang Xiaosheng, Zhu Feng, Visco Carlo, Tzankov Alexandar, Dybkaer Karen, Chiu April, Tam Wayne, Zu Youli, Hsi Eric D, Hagemeister Fredrick B, Huh Jooryung, Ponzoni Maurilio, Ferreri Andrés J M, Møller Michael B, Parsons Benjamin M, Van Krieken J Han, Piris Miguel A, Winter Jane N, Li Yong, Au Qingyan, Xu Bing, Albitar Maher, Young Ken H

Abstract excerpt

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma with high mutation burdens but a low response rate to immune checkpoint inhibitors. In this study, we performed targeted next-generation sequencing and fluorescent multiplex immunohistochemistry, and investigated the clinical significance and immunological effect of mutation numbers in 424 DLBCL patients treated with standard...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, Large B-Cell, Diffuse

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Identifiers

PMID: 34350060
DOI: 10.1080/2162402X.2021.1928365
PMCID: PMC8293967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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