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Article

Intracellular regulation of human ClC-5 by adenine nucleotides.

EMBO reports - 1 Oct 2009

Zifarelli Giovanni, Pusch Michael

Abstract excerpt

ClC-5, an endosomal Cl(-)/H(+) antiporter that is mutated in Dent disease, is essential for endosomal acidification and re-uptake of small molecular weight proteins in the renal proximal tubule. Eukaryotic chloride channels (CLCs) contain two cytoplasmic CBS domains, motifs present in different proteins, the function of which is still poorly understood. Structural studies have shown that ClC-5 can bind to ATP at...

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Identifiers

PMID: 19713962
DOI: 10.1038/embor.2009.159
PMCID: PMC2759731

Genes

CBS
CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Intracellular regulation of human ClC-5 by adenine nucleotides.PMID 19713962Read ↗

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