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Triple-negative breast cancer metastasis involves complex epithelial-mesenchymal transition dynamics and requires vimentin

3 Aug 2022

Abstract excerpt

Triple-negative breast cancer (TNBC) is an aggressive subtype associated with early metastatic recurrence and worse patient outcomes. TNBC tumors express molecular markers of the epithelial-mesenchymal transition (EMT), but its requirement during spontaneous TNBC metastasis in vivo remains incompletely understood. We demonstrated that spontaneous TNBC tumors from a genetically engineered mouse model (GEMM),...

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PMID: 35921474
DOI: 10.1126/scitranslmed.abn7571

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