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Article

Epithelial–mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis

4 Sept 2008

Abstract excerpt

Epithelial-mesenchymal transition (EMT) has been linked to metastatic propensity. The 4T1 tumor is a clinically relevant model of spontaneous breast cancer metastasis. Here we characterize 4T1-derived cell lines for EMT, in vitro invasiveness and in vivo metastatic ability. Contrary to expectations, 67NR cells, which form primary tumors but fail to metastasize, express vimentin and N-cadherin, but not E-cadherin....

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PMID: 18773493
DOI: 10.1002/dvdy.21658

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