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Hybrid epithelial/mesenchymal phenotype(s): The 'fittest' for metastasis?

Biochimica et biophysica acta. Reviews on cancer - 1 Dec 2018

Jolly Mohit Kumar, Mani Sendurai A, Levine Herbert

Abstract excerpt

Metastasis is the leading cause of mortality among cancer patients. Dissemination enabled by an epithelial-to-mesenchymal transition (EMT) of carcinoma cells has long been considered to be the predominant mechanism for carcinoma metastasis, based on overexpression studies of many EMT-inducing transcription factors. Individual CTCs - and a binary framework of EMT - have been long considered to be sufficient and...

Topics

Animals
Cell Transdifferentiation
Epithelial-Mesenchymal Transition
Humans
Neoplasm Invasiveness
Neoplasms
Neoplastic Cells, Circulating
Phenotype

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29997040
DOI: 10.1016/j.bbcan.2018.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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