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Article

Genetic insights into the mechanisms of proliferative glomerulonephritis.

The Journal of clinical investigation - 1 Aug 2024

Hall Gentzon

Abstract excerpt

Glomerular visceral epithelial cells (i.e., podocytes) are an essential component of the tripartite glomerular filtration barrier. Healthy podocytes are terminally differentiated cells with limited replicative capacity; however, inappropriate cell cycle reentry can be induced in podocytes by various injurious stimuli. In this issue of the JCI, Yamaguchi et al. report on a somatic mosaic gain-of-function mutation...

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Share to Cell Proliferation
Share to Class I Phosphatidylinositol 3-Kinases
Share to Glomerulonephritis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glomerulonephritis, Membranoproliferative

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Source

Open in PubMed Open full text

Identifiers

PMID: 39087471
DOI: 10.1172/JCI183090
PMCID: PMC11291265

Genes

PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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