Article
Investigation of the effect of donor platelet endothelial cell adhesion molecule 1 polymorphism on the graft-vs.-host disease occurrence in Tunisian recipients of hematopoietic stem cells.
Clinical biochemistry - 1 Jun 2011
Sellami Mohamed Hichem, Torjemane Lamia, Ladeb Saloua, Kaabi Houda, Ben Ahmed Amira, Cherif Ghaya, Midouni Brahim, Ben Othmane Tarek, Hmida Slama
Abstract excerpt
OBJECTIVE: The aim of this study is to examine the effect of donor PECAM-1 alleles and haplotypes for the SNPs L98V, S536N, and R643G on the occurrence of GVHD in Tunisian recipients of HSCs. DESIGN AND METHODS: This study enrolled 102 patients and their 102 respective HLA-identical sibling donors of HSCs. The PECAM-1 SNPs genotyping assay was performed using sets of sequence specific primers (SSP-PCR). RESULTS:...
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