Article
Effect of donor CTLA-4 alleles and haplotypes on graft-versus-host disease occurrence in Tunisian patients receiving a human leukocyte antigen-identical sibling hematopoietic stem cell transplant.
Human immunology - 1 Feb 2011
Sellami Mohamed Hichem, Bani Meriem, Torjemane Lamia, Kaabi Houda, Ladeb Saloua, Ben Othmane Tarek, Hmida Slama
Abstract excerpt
The CTLA-4 genetic variation, such as single nucleotide polymorphisms (SNPs) may be critical and can affect the functional activity of cells that initiate the graft-versus-host disease (GVHD) effects. The aim of this study is to examine the effect of donor CTLA-4 alleles and haplotypes for the -318C>T and the 49A>G polymorphisms on the occurrence of GVHD in Tunisians recipients of HSCs. A total of 112 patients...
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