Article
Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies.
The Lancet. Oncology - 1 Apr 2013
Rushlow Diane E, Mol Berber M, Kennett Jennifer Y, Yee Stephanie, Pajovic Sanja, Thériault Brigitte L, Prigoda-Lee Nadia L, Spencer Clarellen, Dimaras Helen, Corson Timothy W, Pang Renée, Massey Christine, Godbout Roseline, Jiang Zhe, Zacksenhaus Eldad, Paton Katherine, Moll Annette C, Houdayer Claude, Raizis Anthony, Halliday William, Lam Wan L, Boutros Paul C, Lohmann Dietmar, Dorsman Josephine C, Gallie Brenda L
Abstract excerpt
BACKGROUND: Retinoblastoma is the childhood retinal cancer that defined tumour-suppressor genes. Previous work shows that mutation of both alleles of the RB1 retinoblastoma suppressor gene initiates disease. We aimed to characterise non-familial retinoblastoma tumours with no detectable RB1 mutations. METHODS: Of 1068 unilateral non-familial retinoblastoma tumours, we compared those with no evidence of RB1...
Topics
- Alleles
- Cell Line, Tumor
- Child
- Child, Preschool
- Female
- Gene Amplification
- Gene Dosage
- Gene Expression Regulation, Neoplastic