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Article

Enantiocomplementary Epoxidation Reactions Catalyzed by an Engineered Cofactor-Independent Non-natural Peroxygenase.

Angewandte Chemie (International ed. in English) - 22 Jun 2020

Xu Guangcai, Crotti Michele, Saravanan Thangavelu, Kataja Kim M, Poelarends Gerrit J

Abstract excerpt

Peroxygenases are heme-dependent enzymes that use peroxide-borne oxygen to catalyze a wide range of oxyfunctionalization reactions. Herein, we report the engineering of an unusual cofactor-independent peroxygenase based on a promiscuous tautomerase that accepts different hydroperoxides (t-BuOOH and H2 O2 ) to accomplish enantiocomplementary epoxidations of various α,β-unsaturated aldehydes (citral and substituted...

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Identifiers

PMID: 32160395
DOI: 10.1002/anie.202001373
PMCID: PMC7317984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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