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Multi-gene panel analysis in BRCA1/2-negative patients suspected of hereditary breast and ovarian cancer syndrome: Real-world data from a single institution.

The journal of obstetrics and gynaecology research - 1 Sept 2024

Nakahara Mariko, Ushiama Mineko, Tanabe Noriko, Gotoh Masahiro, Sakamoto Hiromi, Yoshida Teruhiko, Hirata Makoto

Abstract excerpt

AIM: Although BRCA1/2 is most frequently associated with hereditary breast and ovarian cancer (HBOC), many other related genes have been implicated. Therefore, we investigated the prevalence of non-BRCA1/2 genes associated with hereditary cancer predisposition in BRCA1/2-negative patients from the Department of Genetic Medicine and Services with breast and ovarian cancer using a multi-gene panel (MGP) analysis....

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PMID: 39077936
DOI: 10.1111/jog.16026

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