Article
Quantifying KRAS G12C Covalent Drug Inhibitor Activity in Mouse Tumors Using Mass Spectrometry.
Analytical chemistry - 21 Mar 2023
Tran John C, Hunsaker Thomas, Bell Christina, Ma Taylur P, Chan Emily, Larrocha Pablo Saenz-Lopez, Homyk Kelsey, Liu Liling, La Hank, Mao Jialin, de la Cruz Cecile C, Yu Kebing, Beresini Maureen, Forrest William F, Xiao Yang, Jang Anne, Samus Natalia, Stesco Nicholas Dupuis, Mentinova Marija, Parent Stephane, Pottiez Gwenael, Schirm Michael, Purkey Hans E, Liu Yichin, Merchant Mark
Abstract excerpt
The growing opportunities recognized for covalent drug inhibitors, like KRAS G12C inhibitors, are driving the need for mass spectrometry methods that can quickly and robustly measure therapeutic drug activity in vivo for drug discovery research and development. Effective front-end sample preparation is critical for proteins extracted from tumors but is generally labor intensive and impractical for large sample...
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