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Article

Hippo pathway inactivation through subcellular localization of NF2/merlin in outer cells of mouse embryos.

Development (Cambridge, England) - 15 Jul 2024

Goda Nanami, Ito Yui, Saito Shun, Suzuki Miyabi, Bai Hanako, Takahashi Masashi, Wakai Takuya, Kawahara Manabu

Abstract excerpt

The Hippo pathway plays a crucial role in cell proliferation and differentiation during tumorigenesis, tissue homeostasis and early embryogenesis. Scaffold proteins from the ezrin-radixin-moesin (ERM) family, including neurofibromin 2 (NF2; Merlin), regulate the Hippo pathway through cell polarity. However, the mechanisms underlying Hippo pathway regulation via cell polarity in establishing outer cells remain...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39077779
DOI: 10.1242/dev.202639

Genes

NF2
YAP1
LATS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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