Article
UMOD Genotype-Blinded Trial of Ambulatory Blood Pressure Response to Torasemide.
Hypertension (Dallas, Tex. : 1979) - 1 Oct 2024
McCallum Linsay, Lip Stefanie, McConnachie Alex, Brooksbank Katriona, MacIntyre Iain M, Doney Alexander, Llano Andrea, Aman Alisha, Caparrotta Thomas M, Ingram Gareth, Mackenzie Isla S, Dominiczak Anna F, MacDonald Thomas M, Webb David J, Padmanabhan Sandosh
Abstract excerpt
BACKGROUND: UMOD (uromodulin) has been linked to hypertension through potential activation of Na+-K+-2Cl- cotransporter (NKCC2), a target of loop diuretics. We posited that hypertensive patients carrying the rs13333226-AA UMOD genotype would demonstrate greater blood pressure responses to loop diuretics, potentially mediated by this UMOD/NKCC2 interaction. METHODS: This prospective, multicenter, genotype-blinded...
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