Article
Rationale and Design of the Genotype-Blinded Trial of Torasemide for the Treatment of Hypertension (BHF UMOD).
American journal of hypertension - 18 Feb 2021
McCallum Linsay, Brooksbank Katriona, McConnachie Alex, Aman Alisha, Lip Stefanie, Dawson Jesse, MacIntyre Iain M, MacDonald Thomas M, Webb David J, Padmanabhan Sandosh
Abstract excerpt
BACKGROUND: Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near the uromodulin gene (UMOD) affecting uromodulin excretion and blood pressure (BP). Uromodulin is almost exclusively expressed in the thick ascending limb (TAL) of the loop of Henle and its effect on BP appears to be mediated via the TAL sodium transporter, NKCC2. Loop-diuretics block NKCC2 but are not commonly...
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